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mu opioid antagonist naltrexone partially abolishes the antidepressant placebo effect and reduces orbitofrontal cortex encoding of reinforcement

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By targeting multiple metabolic pathways, Survodutide may offer superior efficacy in reducing liver fat and improving overall metabolic health, making it a promising candidate for MASH treatment

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Orlistat (13.6%) and metformin (8.5%) were among the non-GLP-1 agents studied